Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4341775..4342379 Replicon chromosome
Accession NZ_CP104284
Organism Enterobacter hormaechei subsp. steigerwaltii strain JT.WLB1A

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag N2K85_RS20430 Protein ID WP_071788668.1
Coordinates 4342194..4342379 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag N2K85_RS20425 Protein ID WP_023295606.1
Coordinates 4341775..4342179 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K85_RS20410 (N2K85_20410) 4337315..4338133 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
N2K85_RS20415 (N2K85_20415) 4338359..4339759 + 1401 WP_047062387.1 MFS transporter -
N2K85_RS20420 (N2K85_20420) 4339770..4341719 + 1950 WP_047062388.1 glycoside hydrolase family 127 protein -
N2K85_RS20425 (N2K85_20425) 4341775..4342179 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N2K85_RS20430 (N2K85_20430) 4342194..4342379 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
N2K85_RS20435 (N2K85_20435) 4342629..4344167 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
N2K85_RS20440 (N2K85_20440) 4344334..4345218 + 885 WP_015572761.1 ROK family protein -
N2K85_RS20445 (N2K85_20445) 4345222..4347060 - 1839 WP_260673236.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T257471 WP_071788668.1 NZ_CP104284:c4342379-4342194 [Enterobacter hormaechei subsp. steigerwaltii]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT257471 WP_023295606.1 NZ_CP104284:c4342179-4341775 [Enterobacter hormaechei subsp. steigerwaltii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References