Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3669128..3669785 Replicon chromosome
Accession NZ_CP104284
Organism Enterobacter hormaechei subsp. steigerwaltii strain JT.WLB1A

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag N2K85_RS17190 Protein ID WP_017382887.1
Coordinates 3669128..3669538 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag N2K85_RS17195 Protein ID WP_003863437.1
Coordinates 3669519..3669785 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K85_RS17170 (N2K85_17170) 3665126..3666859 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
N2K85_RS17175 (N2K85_17175) 3666865..3667578 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N2K85_RS17180 (N2K85_17180) 3667607..3668503 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
N2K85_RS17185 (N2K85_17185) 3668605..3669126 + 522 WP_015571793.1 flavodoxin FldB -
N2K85_RS17190 (N2K85_17190) 3669128..3669538 - 411 WP_017382887.1 protein YgfX Toxin
N2K85_RS17195 (N2K85_17195) 3669519..3669785 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
N2K85_RS17200 (N2K85_17200) 3670080..3671060 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
N2K85_RS17205 (N2K85_17205) 3671172..3671831 - 660 WP_003863433.1 hemolysin III family protein -
N2K85_RS17210 (N2K85_17210) 3672098..3672829 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
N2K85_RS17215 (N2K85_17215) 3672946..3674379 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T257470 WP_017382887.1 NZ_CP104284:c3669538-3669128 [Enterobacter hormaechei subsp. steigerwaltii]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT257470 WP_003863437.1 NZ_CP104284:c3669785-3669519 [Enterobacter hormaechei subsp. steigerwaltii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References