Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2239423..2240162 Replicon chromosome
Accession NZ_CP104284
Organism Enterobacter hormaechei subsp. steigerwaltii strain JT.WLB1A

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag N2K85_RS10575 Protein ID WP_003857133.1
Coordinates 2239423..2239908 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag N2K85_RS10580 Protein ID WP_003857131.1
Coordinates 2239896..2240162 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K85_RS10545 (N2K85_10545) 2234897..2235511 + 615 WP_080300286.1 NUDIX hydrolase -
N2K85_RS10550 (N2K85_10550) 2235695..2236330 - 636 WP_015570517.1 DUF421 domain-containing protein -
N2K85_RS10555 (N2K85_10555) 2236340..2236786 - 447 WP_014069654.1 DUF3290 domain-containing protein -
N2K85_RS10560 (N2K85_10560) 2237215..2237543 - 329 Protein_2057 ISNCY family transposase -
N2K85_RS10565 (N2K85_10565) 2237822..2238787 + 966 WP_058689390.1 hypothetical protein -
N2K85_RS10570 (N2K85_10570) 2238803..2239372 + 570 WP_032648331.1 hypothetical protein -
N2K85_RS10575 (N2K85_10575) 2239423..2239908 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
N2K85_RS10580 (N2K85_10580) 2239896..2240162 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
N2K85_RS10585 (N2K85_10585) 2240226..2241155 - 930 WP_023296630.1 LysR family transcriptional regulator -
N2K85_RS10590 (N2K85_10590) 2241285..2242667 + 1383 WP_260673351.1 MFS transporter -
N2K85_RS10595 (N2K85_10595) 2242690..2243685 - 996 WP_048247348.1 DUF2891 domain-containing protein -
N2K85_RS10600 (N2K85_10600) 2243695..2244681 - 987 WP_047637343.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T257463 WP_003857133.1 NZ_CP104284:c2239908-2239423 [Enterobacter hormaechei subsp. steigerwaltii]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT257463 WP_003857131.1 NZ_CP104284:c2240162-2239896 [Enterobacter hormaechei subsp. steigerwaltii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References