Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4470582..4471079 Replicon chromosome
Accession NZ_CP104274
Organism Escherichia coli strain Ec15103

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N2O69_RS21980 Protein ID WP_001173343.1
Coordinates 4470582..4470755 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag N2O69_RS21985 Protein ID WP_001312331.1
Coordinates 4470783..4471079 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2O69_RS21970 (4467252) 4467252..4468709 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
N2O69_RS21975 (4468946) 4468946..4470463 + 1518 WP_000003806.1 lysine--tRNA ligase -
N2O69_RS21980 (4470582) 4470582..4470755 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N2O69_RS21985 (4470783) 4470783..4471079 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N2O69_RS21990 (4471308) 4471308..4471580 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
N2O69_RS21995 (4471592) 4471592..4471822 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
N2O69_RS22000 (4472003) 4472003..4473634 + 1632 WP_001216482.1 sensor histidine kinase -
N2O69_RS22005 (4473631) 4473631..4474350 + 720 WP_001540474.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4401837..4471079 69242


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T257455 WP_001173343.1 NZ_CP104274:c4470755-4470582 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT257455 WP_001312331.1 NZ_CP104274:c4471079-4470783 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References