257453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4200673..4201487 Replicon chromosome
Accession NZ_CP104274
Organism Escherichia coli strain Ec15103

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag N2O69_RS20600 Protein ID WP_001054376.1
Coordinates 4200673..4200930 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID S1NWL7
Locus tag N2O69_RS20605 Protein ID WP_001540600.1
Coordinates 4200942..4201487 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2O69_RS20575 (4195961) 4195961..4197067 + 1107 WP_001774143.1 N-acetylneuraminate epimerase -
N2O69_RS20580 (4197132) 4197132..4198112 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
N2O69_RS20585 (4198222) 4198222..4198427 + 206 Protein_4030 HNH endonuclease -
N2O69_RS20590 (4198695) 4198695..4199935 - 1241 Protein_4031 helicase YjhR -
N2O69_RS20595 (4200051) 4200051..4200182 + 132 WP_001309182.1 hypothetical protein -
N2O69_RS20600 (4200673) 4200673..4200930 + 258 WP_001054376.1 YjhX family toxin Toxin
N2O69_RS20605 (4200942) 4200942..4201487 + 546 WP_001540600.1 N-acetyltransferase Antitoxin
N2O69_RS20610 (4201543) 4201543..4202289 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
N2O69_RS20615 (4202458) 4202458..4202676 + 219 Protein_4036 hypothetical protein -
N2O69_RS20620 (4202714) 4202714..4202830 + 117 Protein_4037 VOC family protein -
N2O69_RS20625 (4203075) 4203075..4204196 + 1122 WP_000010829.1 M42 family metallopeptidase -
N2O69_RS20630 (4204193) 4204193..4204471 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
N2O69_RS20635 (4204483) 4204483..4205796 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4190459..4209711 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T257453 WP_001054376.1 NZ_CP104274:4200673-4200930 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT257453 WP_001540600.1 NZ_CP104274:4200942-4201487 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB S1NWL7

References