Detailed information of TA system TA025745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1432640..1433187
• Replicon: chromosome
• Accession: NC_016602
• Organism: Vibrio furnissii NCTC 11218

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0Q2UZ79
• Locus tag: VFU_RS06870
• Protein ID: WP_014204722.1
• Coordinates: 1432885..1433187 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: VFU_RS06865
• Protein ID: WP_014204721.1
• Coordinates: 1432640..1432897 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VFU_RS06840	1427959..1428486	+	528	WP_004725085.1	TRAP transporter small permease	-
VFU_RS06845	1428496..1429803	+	1308	WP_014204717.1	TRAP transporter large permease	-
VFU_RS06850	1429918..1430682	+	765	WP_014204718.1	IclR family transcriptional regulator	-
VFU_RS06855	1431409..1431852	+	444	WP_041942512.1	hypothetical protein	-
VFU_RS22935	1431867..1431959	+	93	WP_081454186.1	DUF3265 domain-containing protein	-
VFU_RS06860	1432016..1432492	+	477	WP_041942513.1	hypothetical protein	-
VFU_RS06865	1432640..1432897	+	258	WP_014204721.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VFU_RS06870	1432885..1433187	+	303	WP_014204722.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VFU_RS06875	1433578..1433853	-	276	WP_004725092.1	hypothetical protein	-
VFU_RS06880	1434194..1434724	-	531	WP_004725093.1	copper resistance protein NlpE	-
VFU_RS06885	1434861..1435148	-	288	WP_014204723.1	hypothetical protein	-
VFU_RS06890	1435223..1436215	-	993	WP_014204724.1	OmpA family protein	-
VFU_RS06895	1436215..1437072	-	858	WP_004725096.1	flagellar motor stator protein MotA	-
VFU_RS06900	1437082..1437810	-	729	WP_004725097.1	FliA/WhiG family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11718.66 Da
• Isoelectric Point: 4.8604

>T25745 WP_014204722.1 NC_016602:1432885-1433187 [Vibrio furnissii NCTC 11218]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFAKVERLENFPESGRIPPELAHLSYRELVVNPCRIFYKFDGDKV
FILFVMRSERDLRKYLLNMQ

Nucleotide

• Length: 303 bp

>T25745 NC_016602:1432885-1433187 [Vibrio furnissii NCTC 11218]
ATGGCTGAAATAATCTGGACGGAGCCTGCGTTATCTGACCTCAATGATATTGCTGAATACATCGCACTTGAAAATATTGT
CGCTGCAAAGCAATTGGTTCAAACGATCTTCGCTAAAGTTGAACGCCTCGAAAATTTCCCCGAATCGGGTCGTATTCCGC
CCGAACTTGCACATCTCAGTTATCGTGAACTGGTCGTGAACCCATGCCGTATTTTCTATAAATTTGACGGCGATAAAGTG
TTTATTCTGTTTGTGATGCGTTCTGAGAGAGATTTGCGCAAGTACTTATTGAACATGCAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9687.26 Da
• Isoelectric Point: 8.5255

>AT25745 WP_014204721.1 NC_016602:1432640-1432897 [Vibrio furnissii NCTC 11218]
MKVELVTSLKRQATKILADLRSTKEPVLITEHGKPSAYLVDVEDYEFMQNRLVILEGIARGERAFADGKVVSHEEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT25745 NC_016602:1432640-1432897 [Vibrio furnissii NCTC 11218]
ATGAAAGTAGAACTCGTGACATCGCTCAAACGTCAAGCTACGAAGATCCTTGCTGATCTCCGTAGCACGAAAGAACCTGT
ACTCATTACTGAACACGGTAAACCGTCGGCGTATCTAGTTGACGTTGAGGATTATGAGTTTATGCAAAATCGTTTGGTGA
TTTTGGAGGGGATTGCGCGCGGTGAGCGTGCATTCGCTGACGGTAAAGTGGTGAGCCACGAGGAAGCCAAGGACAAAATG
TCGAAATGGCTGAAATAA

Structures

Toxin

• AlphaFold DB: A0A0Q2UZ79