Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5086463..5087071 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag PALA1_RS24225 Protein ID WP_003114156.1
Coordinates 5086463..5086810 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA1_RS24230 Protein ID WP_003114155.1
Coordinates 5086820..5087071 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS24195 (PALA1_04774) 5081822..5082094 + 273 WP_021264275.1 cysteine-rich CWC family protein -
PALA1_RS24200 (PALA1_04775) 5082094..5082786 + 693 WP_015503463.1 16S rRNA pseudouridine(516) synthase -
PALA1_RS24205 (PALA1_04776) 5082922..5083965 + 1044 WP_021264274.1 L,D-transpeptidase -
PALA1_RS24210 (PALA1_04777) 5084045..5084782 + 738 WP_021264273.1 murein L,D-transpeptidase catalytic domain family protein -
PALA1_RS24215 (PALA1_04778) 5085234..5086136 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA1_RS24225 (PALA1_04780) 5086463..5086810 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA1_RS24230 5086820..5087071 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA1_RS24235 (PALA1_04781) 5087285..5088268 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PALA1_RS24240 (PALA1_04782) 5088268..5089560 - 1293 WP_003115206.1 hypothetical protein -
PALA1_RS24245 (PALA1_04784) 5089819..5091081 - 1263 WP_021264270.1 zonular occludens toxin domain-containing protein -
PALA1_RS24250 (PALA1_04785) 5091083..5091433 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5086463..5107660 21197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T257431 WP_003114156.1 NZ_CP104254:c5086810-5086463 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT257431 WP_003114155.1 NZ_CP104254:c5087071-5086820 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References