Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4699543..4700801 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name - Uniprot ID A0A509JCW5
Locus tag PALA1_RS22325 Protein ID WP_021264413.1
Coordinates 4699543..4700298 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA1_RS22330 Protein ID WP_003086329.1
Coordinates 4700433..4700801 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS22315 (PALA1_04407) 4694714..4697257 + 2544 WP_023101446.1 acyl-homoserine-lactone acylase QuiP -
PALA1_RS22320 (PALA1_04408) 4697412..4698773 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA1_RS22325 (PALA1_04409) 4699543..4700298 - 756 WP_021264413.1 RES family NAD+ phosphorylase Toxin
PALA1_RS22330 (PALA1_04410) 4700433..4700801 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA1_RS22335 (PALA1_04411) 4700874..4702160 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA1_RS22340 (PALA1_04412) 4702216..4703805 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA1_RS22345 (PALA1_04413) 4703884..4704360 + 477 WP_019486191.1 elongation factor GreAB -
PALA1_RS22350 4704363..4704638 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28217.33 Da        Isoelectric Point: 8.0554

>T257430 WP_021264413.1 NZ_CP104254:c4700298-4699543 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLQTAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAIRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT257430 WP_003086329.1 NZ_CP104254:c4700801-4700433 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A509JCW5

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References