257429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4457965..4458658 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag PALA1_RS21120 Protein ID WP_003151133.1
Coordinates 4457965..4458342 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag PALA1_RS21125 Protein ID WP_001172026.1
Coordinates 4458323..4458658 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS21105 (PALA1_04174) 4453076..4453921 - 846 WP_003464995.1 AraC family transcriptional regulator -
PALA1_RS21110 (PALA1_04175) 4454158..4457187 - 3030 WP_024015041.1 Tn3 family transposase -
PALA1_RS21115 (PALA1_04176) 4457171..4457773 - 603 WP_010465829.1 recombinase family protein -
PALA1_RS21120 (PALA1_04177) 4457965..4458342 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA1_RS21125 (PALA1_04178) 4458323..4458658 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
PALA1_RS21130 (PALA1_04179) 4458673..4458978 + 306 WP_223198361.1 transposase -
PALA1_RS21135 (PALA1_04180) 4459031..4459357 + 327 WP_000091614.1 hypothetical protein -
PALA1_RS21140 (PALA1_04181) 4459354..4459734 + 381 WP_001054412.1 hypothetical protein -
PALA1_RS21145 4459891..4460223 + 333 WP_238176880.1 DUF3391 domain-containing protein -
PALA1_RS21150 (PALA1_04182) 4460307..4461176 + 870 WP_223198360.1 HD-GYP domain-containing protein -
PALA1_RS21155 (PALA1_04183) 4461586..4461825 + 240 WP_034011918.1 ribbon-helix-helix domain-containing protein -
PALA1_RS21160 (PALA1_04184) 4461825..4462235 + 411 WP_034011919.1 putative toxin-antitoxin system toxin component, PIN family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4436153..4467767 31614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T257429 WP_003151133.1 NZ_CP104254:4457965-4458342 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT257429 WP_001172026.1 NZ_CP104254:4458323-4458658 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References