Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3689414..3690634 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA1_RS17445 Protein ID WP_003110488.1
Coordinates 3690056..3690634 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA1_RS17440 Protein ID WP_021264660.1
Coordinates 3689414..3689968 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS17415 (PALA1_03437) 3684982..3685533 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA1_RS17420 (PALA1_03438) 3685530..3685928 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA1_RS17425 (PALA1_03439) 3685941..3686264 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA1_RS17430 (PALA1_03440) 3686595..3687056 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA1_RS17435 (PALA1_03441) 3687061..3689256 + 2196 WP_023091929.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA1_RS17440 (PALA1_03442) 3689414..3689968 + 555 WP_021264660.1 helix-turn-helix transcriptional regulator Antitoxin
PALA1_RS17445 (PALA1_03443) 3690056..3690634 + 579 WP_003110488.1 HD domain-containing protein Toxin
PALA1_RS17450 (PALA1_03444) 3690631..3691260 - 630 WP_023101338.1 LysE family translocator -
PALA1_RS17455 (PALA1_03445) 3691458..3692645 - 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA1_RS17460 (PALA1_03446) 3692635..3694806 - 2172 WP_003088105.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T257428 WP_003110488.1 NZ_CP104254:3690056-3690634 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT257428 WP_021264660.1 NZ_CP104254:3689414-3689968 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRIKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References