Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 615817..616431 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag PALA1_RS02885 Protein ID WP_071534354.1
Coordinates 615817..615999 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag PALA1_RS02890 Protein ID WP_012077229.1
Coordinates 616027..616431 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS02870 (PALA1_00572) 611505..614276 - 2772 WP_021263067.1 ImpA family metalloprotease -
PALA1_RS02875 614376..614519 + 144 WP_003085001.1 hypothetical protein -
PALA1_RS02880 (PALA1_00573) 614947..615225 + 279 Protein_574 type II toxin-antitoxin system HipA family toxin -
PALA1_RS02885 (PALA1_00574) 615817..615999 + 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
PALA1_RS02890 (PALA1_00575) 616027..616431 + 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PALA1_RS02895 (PALA1_00576) 616474..617445 - 972 WP_012077228.1 hypothetical protein -
PALA1_RS02900 (PALA1_00577) 617430..618128 - 699 WP_033896049.1 hypothetical protein -
PALA1_RS02905 (PALA1_00578) 618128..618667 - 540 WP_012074127.1 hypothetical protein -
PALA1_RS02910 (PALA1_00579) 618664..619584 - 921 WP_269972734.1 hypothetical protein -
PALA1_RS02915 (PALA1_00580) 619581..620291 - 711 WP_012074129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 615817..666488 50671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T257426 WP_071534354.1 NZ_CP104254:615817-615999 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT257426 WP_012077229.1 NZ_CP104254:616027-616431 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References