Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 149293..149798 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA1_RS00665 Protein ID WP_003083773.1
Coordinates 149293..149574 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA1_RS00670 Protein ID WP_003083775.1
Coordinates 149571..149798 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS00640 (PALA1_00124) 144544..145893 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA1_RS00645 (PALA1_00125) 145942..146628 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA1_RS00650 (PALA1_00126) 146729..147463 + 735 WP_003110658.1 GntR family transcriptional regulator -
PALA1_RS00655 (PALA1_00127) 147643..148053 + 411 WP_003110659.1 aegerolysin family protein -
PALA1_RS00660 (PALA1_00128) 148085..148993 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA1_RS00665 (PALA1_00129) 149293..149574 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA1_RS00670 (PALA1_00130) 149571..149798 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA1_RS00675 (PALA1_00131) 149974..150594 - 621 WP_003101226.1 hypothetical protein -
PALA1_RS00680 (PALA1_00132) 150695..151195 + 501 WP_003162763.1 LEA type 2 family protein -
PALA1_RS00685 (PALA1_00133) 151268..151609 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA1_RS00690 (PALA1_00134) 151692..153119 - 1428 WP_003083784.1 GABA permease -
PALA1_RS00695 (PALA1_00135) 153288..154781 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T257425 WP_003083773.1 NZ_CP104254:c149574-149293 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT257425 WP_003083775.1 NZ_CP104254:c149798-149571 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References