Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2933634..2935477 Replicon chromosome
Accession NZ_CP104215
Organism Burkholderia gladioli strain ZN-S4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NYZ96_RS30965 Protein ID WP_105828112.1
Coordinates 2933634..2934599 (+) Length 322 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NYZ96_RS30970 Protein ID WP_036056698.1
Coordinates 2934596..2935477 (+) Length 294 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYZ96_RS30930 (NYZ96_30930) 2928942..2930021 - 1080 WP_017921239.1 porin -
NYZ96_RS30935 (NYZ96_30935) 2930131..2930421 + 291 WP_124083656.1 hypothetical protein -
NYZ96_RS30940 (NYZ96_30940) 2930436..2930753 + 318 WP_013689902.1 non-heme iron oxygenase ferredoxin subunit -
NYZ96_RS30945 (NYZ96_30945) 2930756..2931067 + 312 WP_025097963.1 hypothetical protein -
NYZ96_RS30950 (NYZ96_30950) 2931109..2932218 + 1110 WP_105828011.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NYZ96_RS30955 (NYZ96_30955) 2932211..2932981 + 771 WP_103692094.1 SDR family oxidoreductase -
NYZ96_RS30960 (NYZ96_30960) 2933080..2933607 + 528 WP_036038832.1 cupin domain-containing protein -
NYZ96_RS30965 (NYZ96_30965) 2933634..2934599 + 966 WP_105828112.1 alpha/beta fold hydrolase Toxin
NYZ96_RS30970 (NYZ96_30970) 2934596..2935477 + 882 WP_036056698.1 IclR family transcriptional regulator Antitoxin
NYZ96_RS30975 (NYZ96_30975) 2935474..2936271 + 798 WP_096750801.1 SDR family oxidoreductase -
NYZ96_RS30980 (NYZ96_30980) 2936264..2937937 + 1674 WP_186117230.1 thiamine pyrophosphate-binding protein -
NYZ96_RS30985 (NYZ96_30985) 2937930..2938763 + 834 WP_160294863.1 aspartate dehydrogenase -
NYZ96_RS30990 (NYZ96_30990) 2938840..2940330 + 1491 WP_260531629.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(66-304)

Antitoxin

Transcription regulator IclR, C-terminal

(151-274)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 32639.08 Da        Isoelectric Point: 7.0326

>T257422 WP_105828112.1 NZ_CP104215:2933634-2934599 [Burkholderia gladioli]
MSEIDPRGAEAEAGPDAALAARLGQFPARRIAIGEAGLIGWRESGPAQGAGDSTARAAAGERALPVVLLHGIGSGAASWL
AQLDTLGASRRVLAWDAPGYGESTPVAPASPLAADYAASLAGWLDALAIERCVLVGHSLGAIVAGAFARRHAGRLAGLLL
VSPAAGYGAAPAATRDERRDARLAMLAALGPAGLAEQRSANMLSAHAGEAARAWVRRVMAQVKPAGYTQATHLLANADLA
ADLAAWRAMTDAAGAARVEVMVGAEDGITPPNACERIAAAAGVALRIVPRAGHAGYVEAPERYSALIGAFCARCDESWRQ
A

Download         Length: 966 bp

Antitoxin


Download         Length: 294 a.a.        Molecular weight: 31771.20 Da        Isoelectric Point: 6.5132

>AT257422 WP_036056698.1 NZ_CP104215:2934596-2935477 [Burkholderia gladioli]
MNPTQLALRSEPADSGAPEADAANGAYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSAAPAFSSIRVNVGTRLP
AHATTHGHVLMGDLSEAELRALYPERQLERATRATPDSLEALLALVREDAARGYGISNASFERGISVVTAPVRNDTQRIV
AAVTVTVPKPEIDAALIADGLVEKVVRAANELSRRLNYRSDDENSYLKALGLR

Download         Length: 882 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References