Detailed information of TA system TA025742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 201412..201923
• Replicon: chromosome
• Accession: NC_016599
• Organism: Owenweeksia hongkongensis DSM 17368

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G8R6Q9
• Locus tag: OWEHO_RS00900
• Protein ID: WP_014200563.1
• Coordinates: 201412..201672 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: G8R6R0
• Locus tag: OWEHO_RS00905
• Protein ID: WP_014200564.1
• Coordinates: 201669..201923 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OWEHO_RS00880	198038..198442	+	405	WP_014200559.1	DUF4293 domain-containing protein	-
OWEHO_RS00885	198456..199175	-	720	WP_014200560.1	hypothetical protein	-
OWEHO_RS00890	199222..200685	-	1464	WP_014200561.1	Na+/H+ antiporter NhaC	-
OWEHO_RS00895	200757..201335	-	579	WP_014200562.1	septum formation protein Maf	-
OWEHO_RS00900	201412..201672	-	261	WP_014200563.1	Txe/YoeB family addiction module toxin	Toxin
OWEHO_RS00905	201669..201923	-	255	WP_014200564.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OWEHO_RS00910	202244..203722	-	1479	WP_014200565.1	hypothetical protein	-
OWEHO_RS00915	203982..204905	-	924	WP_014200566.1	geranylgeranylglycerol-phosphate geranylgeranyltransferase	-
OWEHO_RS00920	204905..205438	-	534	WP_014200567.1	HAD hydrolase family protein	-
OWEHO_RS00925	205422..206171	-	750	WP_014200568.1	DUF2520 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10779.42 Da
• Isoelectric Point: 8.9690

>T25742 WP_014200563.1 NC_016599:c201672-201412 [Owenweeksia hongkongensis DSM 17368]
MKLCFVDESWEDYLYWQKTDKKMVSRINRLIKEIARTPYEGIGKPEPLKFKYRGFWSRRIDDEHRIIYRVTDDNEIWIVK
CRFHYD

Nucleotide

• Length: 261 bp

>T25742 NC_016599:c201672-201412 [Owenweeksia hongkongensis DSM 17368]
ATGAAACTGTGTTTTGTTGACGAATCCTGGGAAGACTATCTATACTGGCAGAAAACCGATAAGAAAATGGTTTCCCGAAT
AAATAGGCTCATCAAGGAAATAGCGAGAACCCCGTATGAAGGAATCGGAAAACCCGAACCTCTAAAATTTAAATACCGTG
GTTTTTGGTCAAGAAGAATTGATGATGAACACCGAATCATTTACAGAGTAACTGATGATAATGAAATTTGGATTGTTAAA
TGCAGGTTTCATTATGATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9569.68 Da
• Isoelectric Point: 5.8394

>AT25742 WP_014200564.1 NC_016599:c201923-201669 [Owenweeksia hongkongensis DSM 17368]
MISTNISDFRKDIKSYLNKVTQNFETLIINRGKESGVVVISLEEYNSLQATQHELSSAKNEQRLDSAIAKFRNGQSFSKE
LTEE

Nucleotide

• Length: 255 bp

>AT25742 NC_016599:c201923-201669 [Owenweeksia hongkongensis DSM 17368]
ATGATTTCCACAAATATCTCAGACTTCAGGAAGGACATAAAAAGCTATCTAAATAAAGTCACTCAAAACTTTGAAACCTT
AATAATCAACAGAGGTAAAGAATCTGGAGTGGTGGTAATCTCACTTGAAGAATACAATTCTCTACAAGCTACGCAACACG
AGCTTTCTTCTGCCAAAAATGAACAACGCTTAGATTCGGCTATTGCTAAATTTAGAAATGGACAGTCATTTTCCAAGGAA
CTGACGGAGGAATGA

Structures

Toxin

• AlphaFold DB: G8R6Q9

Antitoxin

• AlphaFold DB: G8R6R0