257413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4096283..4096990 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name ykfI Uniprot ID E0J2C8
Locus tag N1H45_RS20000 Protein ID WP_000691790.1
Coordinates 4096283..4096624 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N1H45_RS20005 Protein ID WP_000939438.1
Coordinates 4096655..4096990 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS19980 (4092272) 4092272..4093537 - 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
N1H45_RS19985 (4093930) 4093930..4094877 - 948 WP_000342500.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
N1H45_RS19990 (4094870) 4094870..4095265 - 396 WP_000152741.1 DUF6088 family protein -
N1H45_RS19995 (4095335) 4095335..4096168 - 834 WP_001192746.1 DUF4942 domain-containing protein -
N1H45_RS20000 (4096283) 4096283..4096624 - 342 WP_000691790.1 TA system toxin CbtA family protein Toxin
N1H45_RS20005 (4096655) 4096655..4096990 - 336 WP_000939438.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N1H45_RS20010 (4096990) 4096990..4097463 - 474 WP_001292742.1 DNA repair protein RadC -
N1H45_RS20015 (4097493) 4097493..4098311 - 819 WP_000761991.1 DUF932 domain-containing protein -
N1H45_RS20020 (4098547) 4098547..4099500 - 954 WP_000290405.1 hypothetical protein -
N1H45_RS20025 (4100093) 4100093..4100707 + 615 WP_000772909.1 inovirus Gp2 family protein -
N1H45_RS20030 (4100825) 4100825..4101043 + 219 WP_001064742.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4063589..4112841 49252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13060.08 Da        Isoelectric Point: 9.4583

>T257413 WP_000691790.1 NZ_CP104206:c4096624-4096283 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCYNTTAR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12639.63 Da        Isoelectric Point: 7.7723

>AT257413 WP_000939438.1 NZ_CP104206:c4096990-4096655 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPWQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J2C8

Antitoxin

Source ID Structure

References