257412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4093930..4095265 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name sanaT Uniprot ID E0J2C5
Locus tag N1H45_RS19985 Protein ID WP_000342500.1
Coordinates 4093930..4094877 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag N1H45_RS19990 Protein ID WP_000152741.1
Coordinates 4094870..4095265 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS19970 (4090063) 4090063..4090605 + 543 WP_001115385.1 hypothetical protein -
N1H45_RS19975 (4090602) 4090602..4092071 + 1470 WP_001022619.1 serine/threonine-protein kinase -
N1H45_RS19980 (4092272) 4092272..4093537 - 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
N1H45_RS19985 (4093930) 4093930..4094877 - 948 WP_000342500.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N1H45_RS19990 (4094870) 4094870..4095265 - 396 WP_000152741.1 DUF6088 family protein Antitoxin
N1H45_RS19995 (4095335) 4095335..4096168 - 834 WP_001192746.1 DUF4942 domain-containing protein -
N1H45_RS20000 (4096283) 4096283..4096624 - 342 WP_000691790.1 TA system toxin CbtA family protein -
N1H45_RS20005 (4096655) 4096655..4096990 - 336 WP_000939438.1 type IV toxin-antitoxin system YeeU family antitoxin -
N1H45_RS20010 (4096990) 4096990..4097463 - 474 WP_001292742.1 DNA repair protein RadC -
N1H45_RS20015 (4097493) 4097493..4098311 - 819 WP_000761991.1 DUF932 domain-containing protein -
N1H45_RS20020 (4098547) 4098547..4099500 - 954 WP_000290405.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4063589..4112841 49252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35562.71 Da        Isoelectric Point: 4.9737

>T257412 WP_000342500.1 NZ_CP104206:c4094877-4093930 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGSTGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT257412 WP_000152741.1 NZ_CP104206:c4095265-4094870 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J2C5

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References