Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3609670..3610167 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N1H45_RS17665 Protein ID WP_001173343.1
Coordinates 3609994..3610167 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag N1H45_RS17660 Protein ID WP_000398619.1
Coordinates 3609670..3609966 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS17640 (3606401) 3606401..3607120 - 720 WP_000611288.1 two-component system response regulator DcuR -
N1H45_RS17645 (3607117) 3607117..3608748 - 1632 WP_001216477.1 sensor histidine kinase -
N1H45_RS17650 (3608929) 3608929..3609159 + 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
N1H45_RS17655 (3609171) 3609171..3609443 + 273 WP_000405651.1 GNAT family N-acetyltransferase -
N1H45_RS17660 (3609670) 3609670..3609966 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N1H45_RS17665 (3609994) 3609994..3610167 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N1H45_RS17670 (3610286) 3610286..3611803 - 1518 WP_001295074.1 lysine--tRNA ligase -
N1H45_RS17675 (3612040) 3612040..3613497 - 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T257410 WP_001173343.1 NZ_CP104206:3609994-3610167 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT257410 WP_000398619.1 NZ_CP104206:3609670-3609966 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References