257409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3341541..3342166 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag N1H45_RS16350 Protein ID WP_000911329.1
Coordinates 3341541..3341939 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N1H45_RS16355 Protein ID WP_000450524.1
Coordinates 3341939..3342166 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS16330 (3337448) 3337448..3337648 + 201 WP_000383836.1 YpfN family protein -
N1H45_RS16335 (3337729) 3337729..3338427 - 699 WP_000679823.1 esterase -
N1H45_RS16340 (3338501) 3338501..3340516 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
N1H45_RS16345 (3340531) 3340531..3341394 - 864 WP_001267505.1 neutral zinc metallopeptidase -
N1H45_RS16350 (3341541) 3341541..3341939 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
N1H45_RS16355 (3341939) 3341939..3342166 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N1H45_RS16360 (3342321) 3342321..3343034 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N1H45_RS16365 (3343247) 3343247..3344281 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N1H45_RS16370 (3344298) 3344298..3345176 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N1H45_RS16375 (3345322) 3345322..3345894 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N1H45_RS16380 (3345894) 3345894..3346364 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T257409 WP_000911329.1 NZ_CP104206:c3341939-3341541 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT257409 WP_000450524.1 NZ_CP104206:c3342166-3341939 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References