257403

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2362285..2362811 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N1H45_RS11545 Protein ID WP_000323025.1
Coordinates 2362285..2362572 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N1H45_RS11550 Protein ID WP_000534858.1
Coordinates 2362572..2362811 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS11495 (2357309) 2357309..2357524 - 216 WP_000839590.1 phage lysis protein EssD -
N1H45_RS11500 (2357744) 2357744..2357914 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
N1H45_RS11505 (2358278) 2358278..2358493 - 216 WP_000066484.1 cold shock-like protein CspB -
N1H45_RS11510 (2358794) 2358794..2359006 + 213 WP_000087756.1 cold shock-like protein CspF -
N1H45_RS11515 (2359061) 2359061..2359150 + 90 WP_120795389.1 hypothetical protein -
N1H45_RS11520 (2359428) 2359428..2360180 - 753 WP_001047135.1 antitermination protein -
N1H45_RS11525 (2360194) 2360194..2361243 - 1050 WP_001265199.1 DUF968 domain-containing protein -
N1H45_RS11530 (2361245) 2361245..2361523 - 279 WP_012304870.1 hypothetical protein -
N1H45_RS11535 (2361590) 2361590..2361841 - 252 WP_000980994.1 protein Rem -
N1H45_RS11540 (2362058) 2362058..2362213 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N1H45_RS11545 (2362285) 2362285..2362572 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N1H45_RS11550 (2362572) 2362572..2362811 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N1H45_RS11555 (2362836) 2362836..2363141 + 306 WP_001326990.1 protein YdfV -
N1H45_RS11560 (2363344) 2363344..2363676 + 333 WP_001301033.1 FlxA-like family protein -
N1H45_RS11565 (2364113) 2364113..2364262 - 150 WP_011443592.1 protein YdfW -
N1H45_RS11570 (2364383) 2364383..2365405 - 1023 Protein_2264 ISNCY family transposase -
N1H45_RS11575 (2366195) 2366195..2366482 - 288 Protein_2265 hypothetical protein -
N1H45_RS11580 (2366960) 2366960..2367449 - 490 Protein_2266 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2328315..2377312 48997
- inside Prophage - - 2329757..2394156 64399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T257403 WP_000323025.1 NZ_CP104206:c2362572-2362285 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT257403 WP_000534858.1 NZ_CP104206:c2362811-2362572 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References