257397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1218157..1218775 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N1H45_RS05895 Protein ID WP_001291435.1
Coordinates 1218157..1218375 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N1H45_RS05900 Protein ID WP_000344800.1
Coordinates 1218401..1218775 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS05860 (1213446) 1213446..1214018 + 573 WP_000779826.1 YbaY family lipoprotein -
N1H45_RS05865 (1214049) 1214049..1214360 - 312 WP_000409911.1 MGMT family protein -
N1H45_RS05875 (1214739) 1214739..1215092 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N1H45_RS05880 (1215134) 1215134..1216684 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N1H45_RS05885 (1216848) 1216848..1217318 - 471 WP_000136192.1 YlaC family protein -
N1H45_RS05890 (1217434) 1217434..1217985 - 552 WP_000102564.1 maltose O-acetyltransferase -
N1H45_RS05895 (1218157) 1218157..1218375 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N1H45_RS05900 (1218401) 1218401..1218775 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N1H45_RS05905 (1219321) 1219321..1222470 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N1H45_RS05910 (1222493) 1222493..1223686 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257397 WP_001291435.1 NZ_CP104206:c1218375-1218157 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257397 WP_000344800.1 NZ_CP104206:c1218775-1218401 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References