Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 885106..885760 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag N1H45_RS04345 Protein ID WP_000244772.1
Coordinates 885353..885760 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N1H45_RS04340 Protein ID WP_000354046.1
Coordinates 885106..885372 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS04315 (880394) 880394..881137 + 744 WP_000951964.1 SDR family oxidoreductase -
N1H45_RS04320 (881194) 881194..882627 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
N1H45_RS04325 (882672) 882672..882983 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
N1H45_RS04330 (883147) 883147..883806 + 660 WP_000250274.1 hemolysin III family protein -
N1H45_RS04335 (883883) 883883..884863 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
N1H45_RS04340 (885106) 885106..885372 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N1H45_RS04345 (885353) 885353..885760 + 408 WP_000244772.1 protein YgfX Toxin
N1H45_RS04350 (885800) 885800..886321 - 522 WP_001055874.1 flavodoxin FldB -
N1H45_RS04355 (886433) 886433..887329 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N1H45_RS04360 (887354) 887354..888064 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N1H45_RS04365 (888070) 888070..889803 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T257394 WP_000244772.1 NZ_CP104206:885353-885760 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT257394 WP_000354046.1 NZ_CP104206:885106-885372 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References