Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 47684..48403 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name yeeV Uniprot ID E0J373
Locus tag N1H45_RS00240 Protein ID WP_001095907.1
Coordinates 47684..48004 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E0J374
Locus tag N1H45_RS00245 Protein ID WP_001192122.1
Coordinates 48038..48403 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS00215 (43362) 43362..43655 - 294 WP_000805509.1 protein YicS -
N1H45_RS00220 (43877) 43877..44695 + 819 WP_000779426.1 lipoprotein NlpA -
N1H45_RS00225 (44699) 44699..45622 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
N1H45_RS00230 (45733) 45733..46917 - 1185 WP_001172876.1 sugar efflux transporter -
N1H45_RS00235 (47314) 47314..47475 - 162 Protein_46 virulence RhuM family protein -
N1H45_RS00240 (47684) 47684..48004 - 321 WP_001095907.1 TA system toxin CbtA family protein Toxin
N1H45_RS00245 (48038) 48038..48403 - 366 WP_001192122.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N1H45_RS00250 (48435) 48435..48656 - 222 WP_000691985.1 DUF987 family protein -
N1H45_RS00255 (48665) 48665..49135 - 471 WP_000104319.1 DNA repair protein RadC -
N1H45_RS00260 (49205) 49205..50026 - 822 WP_000197395.1 DUF932 domain-containing protein -
N1H45_RS00265 (50098) 50098..50589 - 492 WP_244401893.1 hypothetical protein -
N1H45_RS00270 (50791) 50791..51039 - 249 WP_260579116.1 hypothetical protein -
N1H45_RS00275 (51112) 51112..52320 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
N1H45_RS00280 (52330) 52330..52932 - 603 WP_260579117.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12184.76 Da        Isoelectric Point: 5.5740

>T257390 WP_001095907.1 NZ_CP104206:c48004-47684 [Escherichia coli]
MNTPTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVRRAQFNLGLKRS

Download         Length: 321 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13470.22 Da        Isoelectric Point: 6.8421

>AT257390 WP_001192122.1 NZ_CP104206:c48403-48038 [Escherichia coli]
MQSTTLSGTSAENVSCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0J373

Antitoxin

Source ID Structure
AlphaFold DB E0J374

References