Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 188..710 Replicon plasmid pCHN23026_3
Accession NZ_CP104199
Organism Klebsiella pneumoniae strain CHN23026

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N3931_RS27290 Protein ID WP_000220561.1
Coordinates 188..469 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N3931_RS27295 Protein ID WP_000121743.1
Coordinates 459..710 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3931_RS27290 (N3931_27290) 188..469 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N3931_RS27295 (N3931_27295) 459..710 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N3931_RS27300 (N3931_27300) 1945..2784 + 840 WP_024129959.1 replication initiation protein -
N3931_RS27305 (N3931_27305) 2805..3647 + 843 WP_000435064.1 replication initiation protein -
N3931_RS27310 (N3931_27310) 3651..4097 + 447 WP_001074384.1 hypothetical protein -
N3931_RS27315 (N3931_27315) 4234..4587 + 354 WP_024129958.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid rmtB / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / blaTEM-1B / blaCTX-M-55 / aph(3')-IIa - 1..49316 49316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T257388 WP_000220561.1 NZ_CP104199:c469-188 [Klebsiella pneumoniae]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT257388 WP_000121743.1 NZ_CP104199:c710-459 [Klebsiella pneumoniae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References