Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4936531..4938212 Replicon chromosome
Accession NZ_CP104196
Organism Klebsiella pneumoniae strain CHN23026

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag N3931_RS24480 Protein ID WP_002885155.1
Coordinates 4936531..4937448 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag N3931_RS24485 Protein ID WP_004151732.1
Coordinates 4937454..4938212 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3931_RS24460 (N3931_24460) 4931837..4933357 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
N3931_RS24465 (N3931_24465) 4933354..4934352 + 999 WP_002885172.1 ribose ABC transporter permease -
N3931_RS24470 (N3931_24470) 4934383..4935324 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
N3931_RS24475 (N3931_24475) 4935399..4936406 + 1008 WP_004151731.1 carbohydrate kinase family protein -
N3931_RS24480 (N3931_24480) 4936531..4937448 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N3931_RS24485 (N3931_24485) 4937454..4938212 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
N3931_RS24490 (N3931_24490) 4938298..4939026 - 729 WP_002885152.1 response regulator transcription factor -
N3931_RS24495 (N3931_24495) 4939299..4941446 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
N3931_RS24500 (N3931_24500) 4941676..4942362 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T257384 WP_002885155.1 NZ_CP104196:c4937448-4936531 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT257384 WP_004151732.1 NZ_CP104196:c4938212-4937454 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References