Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4780347..4780863 Replicon chromosome
Accession NZ_CP104196
Organism Klebsiella pneumoniae strain CHN23026

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag N3931_RS23680 Protein ID WP_002886902.1
Coordinates 4780347..4780631 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N3931_RS23685 Protein ID WP_002886901.1
Coordinates 4780621..4780863 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3931_RS23655 (N3931_23655) 4775831..4776094 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
N3931_RS23660 (N3931_23660) 4776224..4776397 + 174 WP_002886906.1 hypothetical protein -
N3931_RS23665 (N3931_23665) 4776400..4777143 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N3931_RS23670 (N3931_23670) 4777500..4779638 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
N3931_RS23675 (N3931_23675) 4779879..4780343 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N3931_RS23680 (N3931_23680) 4780347..4780631 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N3931_RS23685 (N3931_23685) 4780621..4780863 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N3931_RS23690 (N3931_23690) 4780941..4782851 - 1911 WP_004152270.1 PRD domain-containing protein -
N3931_RS23695 (N3931_23695) 4782874..4784028 - 1155 WP_002886900.1 lactonase family protein -
N3931_RS23700 (N3931_23700) 4784094..4784834 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T257383 WP_002886902.1 NZ_CP104196:c4780631-4780347 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT257383 WP_002886901.1 NZ_CP104196:c4780863-4780621 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References