Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4677438..4678248 Replicon chromosome
Accession NZ_CP104196
Organism Klebsiella pneumoniae strain CHN23026

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag N3931_RS23195 Protein ID WP_002887280.1
Coordinates 4677438..4677971 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag N3931_RS23200 Protein ID WP_002887278.1
Coordinates 4677982..4678248 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3931_RS23190 (N3931_23190) 4676269..4677390 + 1122 WP_002887282.1 cupin domain-containing protein -
N3931_RS23195 (N3931_23195) 4677438..4677971 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
N3931_RS23200 (N3931_23200) 4677982..4678248 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
N3931_RS23205 (N3931_23205) 4678351..4679784 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
N3931_RS23210 (N3931_23210) 4679774..4680457 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
N3931_RS23215 (N3931_23215) 4680629..4682014 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
N3931_RS23220 (N3931_23220) 4682032..4682376 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T257382 WP_002887280.1 NZ_CP104196:c4677971-4677438 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT257382 WP_002887278.1 NZ_CP104196:c4678248-4677982 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References