Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874345..875002 Replicon chromosome
Accession NZ_CP104196
Organism Klebsiella pneumoniae strain CHN23026

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N3931_RS04430 Protein ID WP_002916310.1
Coordinates 874592..875002 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N3931_RS04425 Protein ID WP_002916312.1
Coordinates 874345..874611 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3931_RS04400 (N3931_04400) 869501..870934 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
N3931_RS04405 (N3931_04405) 871053..871781 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N3931_RS04410 (N3931_04410) 871831..872142 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
N3931_RS04415 (N3931_04415) 872306..872965 + 660 WP_002916317.1 hemolysin III family protein -
N3931_RS04420 (N3931_04420) 873116..874099 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
N3931_RS04425 (N3931_04425) 874345..874611 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N3931_RS04430 (N3931_04430) 874592..875002 + 411 WP_002916310.1 protein YgfX Toxin
N3931_RS04435 (N3931_04435) 875009..875530 - 522 WP_002916308.1 flavodoxin FldB -
N3931_RS04440 (N3931_04440) 875631..876527 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N3931_RS04445 (N3931_04445) 876550..877263 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N3931_RS04450 (N3931_04450) 877269..879002 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T257375 WP_002916310.1 NZ_CP104196:874592-875002 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT257375 WP_002916312.1 NZ_CP104196:874345-874611 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References