Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 6506968..6507608 Replicon chromosome
Accession NZ_CP104172
Organism Bradyrhizobium sp. CB3035

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag N2603_RS30815 Protein ID WP_018647982.1
Coordinates 6506968..6507258 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A562S0U1
Locus tag N2603_RS30820 Protein ID WP_018647983.1
Coordinates 6507258..6507608 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2603_RS30790 (N2603_30790) 6502176..6502814 - 639 WP_018647977.1 DUF1109 domain-containing protein -
N2603_RS30795 (N2603_30795) 6502817..6503362 - 546 WP_018647978.1 sigma-70 family RNA polymerase sigma factor -
N2603_RS30800 (N2603_30800) 6503653..6504327 + 675 WP_260385084.1 hypothetical protein -
N2603_RS30805 (N2603_30805) 6504468..6505247 + 780 WP_260385085.1 enoyl-CoA hydratase -
N2603_RS30810 (N2603_30810) 6505436..6506866 + 1431 WP_260385086.1 TolC family outer membrane protein -
N2603_RS30815 (N2603_30815) 6506968..6507258 + 291 WP_018647982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2603_RS30820 (N2603_30820) 6507258..6507608 + 351 WP_018647983.1 putative addiction module antidote protein Antitoxin
N2603_RS30825 (N2603_30825) 6507694..6508251 + 558 WP_260385087.1 hypothetical protein -
N2603_RS30830 (N2603_30830) 6508302..6509264 + 963 WP_018647985.1 amidohydrolase family protein -
N2603_RS30835 (N2603_30835) 6509267..6512383 - 3117 WP_260385088.1 CusA/CzcA family heavy metal efflux RND transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(14-101)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11098.68 Da        Isoelectric Point: 9.9817

>T257367 WP_018647982.1 NZ_CP104172:6506968-6507258 [Bradyrhizobium sp. CB3035]
MVEVRQTEHFSEWLSRLRDASAVARITVRIRRMEMGNPGDSKSVGRNIREMRIDYGPGYRIYYVQRGAQIVILLCGGDKR
TQRQDIELAQQLAETS

Download         Length: 291 bp

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12215.95 Da        Isoelectric Point: 10.8470

>AT257367 WP_018647983.1 NZ_CP104172:6507258-6507608 [Bradyrhizobium sp. CB3035]
MPKAAKTTAKTASKTTRFDAADYLNTEERQAAYIAAALETGDADFVRDALGLVARARGMSAIAKKAGLNRESLYKALGET
GNPEFGTVMRIVGALGLTLSAQPATSGRTPKRRRAA

Download         Length: 351 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A562S0U1

References