Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6946945..6947578 Replicon chromosome
Accession NZ_CP104171
Organism Bradyrhizobium sp. NC92

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N2602_RS32415 Protein ID WP_260380647.1
Coordinates 6947390..6947578 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N2602_RS32410 Protein ID WP_260380646.1
Coordinates 6946945..6947337 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2602_RS32380 (N2602_32380) 6942454..6942807 - 354 WP_260383760.1 IS66 family insertion sequence element accessory protein TnpB -
N2602_RS32385 (N2602_32385) 6942804..6943265 - 462 WP_260380641.1 transposase -
N2602_RS32390 (N2602_32390) 6943664..6943798 - 135 WP_260380642.1 hypothetical protein -
N2602_RS32395 (N2602_32395) 6944144..6944467 - 324 WP_260380643.1 hypothetical protein -
N2602_RS32400 (N2602_32400) 6944619..6944825 + 207 WP_260380644.1 cold-shock protein -
N2602_RS32405 (N2602_32405) 6944896..6946239 - 1344 WP_260380645.1 IS5 family transposase -
N2602_RS32410 (N2602_32410) 6946945..6947337 - 393 WP_260380646.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N2602_RS32415 (N2602_32415) 6947390..6947578 - 189 WP_260380647.1 type II toxin-antitoxin system HicA family toxin Toxin
N2602_RS32420 (N2602_32420) 6948014..6949258 - 1245 WP_260380648.1 hypothetical protein -
N2602_RS32425 (N2602_32425) 6949255..6950490 - 1236 WP_260380649.1 ATP-grasp domain-containing protein -
N2602_RS32430 (N2602_32430) 6950420..6951616 - 1197 WP_260380650.1 saccharopine dehydrogenase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 6744268..6947578 203310
- flank IS/Tn - - 6944896..6946239 1343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6867.12 Da        Isoelectric Point: 11.2962

>T257366 WP_260380647.1 NZ_CP104171:c6947578-6947390 [Bradyrhizobium sp. NC92]
MKSTDIIAALKADGWTQVAQKGSHVQFKHPIKPGRVTVPHPKKDIPIGTVRSIEKQSVLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13799.56 Da        Isoelectric Point: 4.3227

>AT257366 WP_260380646.1 NZ_CP104171:c6947337-6946945 [Bradyrhizobium sp. NC92]
MRYYIVLIHKDADSDYGVSFPDLPGVISAGSTLDEAREMAAEALALHLRGLAEDGEAVPEPSSLEQIMANADNKDGVAVL
IPAPAEEVKSVRVNITLPADVLSEIDRHAEQQGFTRSGFLAQAAKKALAA

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References