257365

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6107483..6107988 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag NDR95_RS28460 Protein ID WP_003121619.1
Coordinates 6107483..6107764 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag NDR95_RS28465 Protein ID WP_003112628.1
Coordinates 6107761..6107988 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS28435 (NDR95_28435) 6102734..6104083 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
NDR95_RS28440 (NDR95_28440) 6104132..6104818 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NDR95_RS28445 (NDR95_28445) 6104919..6105653 + 735 WP_003117208.1 GntR family transcriptional regulator -
NDR95_RS28450 (NDR95_28450) 6105833..6106243 + 411 WP_003101225.1 aegerolysin family protein -
NDR95_RS28455 (NDR95_28455) 6106275..6107183 - 909 WP_003083769.1 LysR family transcriptional regulator -
NDR95_RS28460 (NDR95_28460) 6107483..6107764 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
NDR95_RS28465 (NDR95_28465) 6107761..6107988 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
NDR95_RS28470 (NDR95_28470) 6108164..6108784 - 621 WP_003101226.1 hypothetical protein -
NDR95_RS28475 (NDR95_28475) 6108885..6109385 + 501 WP_003101228.1 LEA type 2 family protein -
NDR95_RS28480 (NDR95_28480) 6109458..6109799 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NDR95_RS28485 (NDR95_28485) 6109881..6111308 - 1428 WP_003083784.1 GABA permease -
NDR95_RS28490 (NDR95_28490) 6111477..6112970 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T257365 WP_003121619.1 NZ_CP104170:c6107764-6107483 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT257365 WP_003112628.1 NZ_CP104170:c6107988-6107761 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References