257363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4640890..4641530 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NDR95_RS21765 Protein ID WP_003134109.1
Coordinates 4640890..4641300 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NDR95_RS21770 Protein ID WP_031628173.1
Coordinates 4641300..4641530 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS21735 (NDR95_21735) 4637267..4637995 + 729 WP_260352473.1 TIGR03761 family integrating conjugative element protein -
NDR95_RS21740 (NDR95_21740) 4638001..4638549 + 549 WP_260352475.1 DUF3158 family protein -
NDR95_RS21745 (NDR95_21745) 4638597..4639439 + 843 WP_016264250.1 Rha family transcriptional regulator -
NDR95_RS21750 (NDR95_21750) 4639469..4639957 + 489 WP_003134107.1 single-stranded DNA-binding protein -
NDR95_RS21755 (NDR95_21755) 4640214..4640381 + 168 WP_128729268.1 CrpP family ICE-associated protein -
NDR95_RS21760 (NDR95_21760) 4640677..4640874 - 198 WP_260352484.1 hypothetical protein -
NDR95_RS21765 (NDR95_21765) 4640890..4641300 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
NDR95_RS21770 (NDR95_21770) 4641300..4641530 - 231 WP_031628173.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NDR95_RS21775 (NDR95_21775) 4641848..4642729 + 882 Protein_4299 DNA topoisomerase -
NDR95_RS21780 (NDR95_21780) 4642845..4644344 + 1500 WP_101516663.1 IS21-like element ISPst3 family transposase -
NDR95_RS21785 (NDR95_21785) 4644337..4645140 + 804 WP_011911830.1 IS21-like element ISPst3 family helper ATPase IstB -
NDR95_RS21790 (NDR95_21790) 4645374..4646039 + 666 WP_260352489.1 helicase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4622315..4651767 29452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T257363 WP_003134109.1 NZ_CP104170:c4641300-4640890 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8450.32 Da        Isoelectric Point: 4.2821

>AT257363 WP_031628173.1 NZ_CP104170:c4641530-4641300 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDSEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References