257361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3932798..3934056 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag NDR95_RS18390 Protein ID WP_003086331.1
Coordinates 3932798..3933553 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NDR95_RS18395 Protein ID WP_003086329.1
Coordinates 3933688..3934056 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS18380 (NDR95_18380) 3927970..3930513 + 2544 WP_119565218.1 acyl-homoserine-lactone acylase QuiP -
NDR95_RS18385 (NDR95_18385) 3930668..3932029 - 1362 WP_003081943.1 DNA recombination protein RmuC -
NDR95_RS18390 (NDR95_18390) 3932798..3933553 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
NDR95_RS18395 (NDR95_18395) 3933688..3934056 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NDR95_RS18400 (NDR95_18400) 3934129..3935415 - 1287 WP_119565219.1 FAD-binding oxidoreductase -
NDR95_RS18405 (NDR95_18405) 3935471..3937060 - 1590 WP_079743354.1 aldehyde dehydrogenase family protein -
NDR95_RS18410 (NDR95_18410) 3937139..3937615 + 477 WP_003086322.1 hypothetical protein -
NDR95_RS18415 (NDR95_18415) 3937618..3937893 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T257361 WP_003086331.1 NZ_CP104170:c3933553-3932798 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT257361 WP_003086329.1 NZ_CP104170:c3934056-3933688 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References