Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2998929..3000150 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag NDR95_RS14000 Protein ID WP_003102740.1
Coordinates 2999572..3000150 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NDR95_RS13995 Protein ID WP_003088112.1
Coordinates 2998929..2999483 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS13970 (NDR95_13970) 2994497..2995048 + 552 WP_003102727.1 XRE family transcriptional regulator -
NDR95_RS13975 (NDR95_13975) 2995045..2995443 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NDR95_RS13980 (NDR95_13980) 2995456..2995779 - 324 WP_003102734.1 multidrug efflux SMR transporter -
NDR95_RS13985 (NDR95_13985) 2996110..2996571 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
NDR95_RS13990 (NDR95_13990) 2996576..2998771 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NDR95_RS13995 (NDR95_13995) 2998929..2999483 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NDR95_RS14000 (NDR95_14000) 2999572..3000150 + 579 WP_003102740.1 HD domain-containing protein Toxin
NDR95_RS14005 (NDR95_14005) 3000259..3001446 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
NDR95_RS14010 (NDR95_14010) 3001436..3003607 - 2172 WP_260353293.1 type I secretion system permease/ATPase -
NDR95_RS14015 (NDR95_14015) 3003597..3004874 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T257360 WP_003102740.1 NZ_CP104170:2999572-3000150 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT257360 WP_003088112.1 NZ_CP104170:2998929-2999483 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References