257359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1184908..1186416 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag NDR95_RS05590 Protein ID WP_003119682.1
Coordinates 1184908..1185495 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag NDR95_RS05595 Protein ID WP_003119683.1
Coordinates 1185562..1186416 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS05585 (NDR95_05585) 1181163..1184642 - 3480 WP_260353208.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
NDR95_RS05590 (NDR95_05590) 1184908..1185495 + 588 WP_003119682.1 GNAT family protein Toxin
NDR95_RS05595 (NDR95_05595) 1185562..1186416 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
NDR95_RS05600 (NDR95_05600) 1186513..1188678 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
NDR95_RS05605 (NDR95_05605) 1188853..1190727 + 1875 WP_003117607.1 MFS transporter -
NDR95_RS05610 (NDR95_05610) 1190788..1190997 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T257359 WP_003119682.1 NZ_CP104170:1184908-1185495 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT257359 WP_003119683.1 NZ_CP104170:1185562-1186416 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References