Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 354526..355061 Replicon plasmid pSU277_2
Accession NZ_CP104149
Organism Sinorhizobium medicae strain SU277

Toxin (Protein)


Gene name relE Uniprot ID A0A6G1WU13
Locus tag N2598_RS26775 Protein ID WP_024325581.1
Coordinates 354526..354801 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A508WV74
Locus tag N2598_RS26780 Protein ID WP_011970754.1
Coordinates 354801..355061 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2598_RS26745 (N2598_26745) 350553..350797 + 245 Protein_337 hypothetical protein -
N2598_RS26750 (N2598_26750) 350998..351249 - 252 WP_011970757.1 WGR domain-containing protein -
N2598_RS26755 (N2598_26755) 352093..352383 - 291 WP_024325582.1 hypothetical protein -
N2598_RS26760 (N2598_26760) 352629..352754 + 126 WP_256380305.1 hypothetical protein -
N2598_RS26765 (N2598_26765) 352983..353207 + 225 WP_225996840.1 hypothetical protein -
N2598_RS26770 (N2598_26770) 353328..354477 - 1150 Protein_342 tyrosine-type recombinase/integrase -
N2598_RS26775 (N2598_26775) 354526..354801 - 276 WP_024325581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2598_RS26780 (N2598_26780) 354801..355061 - 261 WP_011970754.1 ribbon-helix-helix domain-containing protein Antitoxin
N2598_RS26785 (N2598_26785) 355194..355523 - 330 WP_011970753.1 hypothetical protein -
N2598_RS26790 (N2598_26790) 355524..355904 - 381 WP_011970752.1 hypothetical protein -
N2598_RS26795 (N2598_26795) 356195..356803 - 609 WP_127581955.1 DUF1003 domain-containing protein -
N2598_RS26800 (N2598_26800) 356894..357727 - 834 WP_011970750.1 DUF1614 domain-containing protein -
N2598_RS26805 (N2598_26805) 357952..359349 - 1398 WP_102045632.1 sigma-54 dependent transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1024067 1024067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10822.40 Da        Isoelectric Point: 9.9707

>T257345 WP_024325581.1 NZ_CP104149:c354801-354526 [Sinorhizobium medicae]
MKLEWTSKAVADLGRLYDFLAPVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9710.05 Da        Isoelectric Point: 4.6413

>AT257345 WP_011970754.1 NZ_CP104149:c355061-354801 [Sinorhizobium medicae]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDADRVIDHQAVQAWADSLDSDK
PLSLPL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G1WU13

Antitoxin

Source ID Structure
AlphaFold DB A0A508WV74

References