Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 503427..504304 Replicon plasmid pSU277_1
Accession NZ_CP104148
Organism Sinorhizobium medicae strain SU277

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N2598_RS20340 Protein ID WP_102046384.1
Coordinates 503852..504304 (+) Length 151 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6G1WRV9
Locus tag N2598_RS20335 Protein ID WP_018012058.1
Coordinates 503427..503798 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2598_RS20315 (N2598_20315) 499316..499699 + 384 WP_018012062.1 RidA family protein -
N2598_RS20320 (N2598_20320) 499716..501704 + 1989 WP_024312177.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
N2598_RS20325 (N2598_20325) 501701..502570 + 870 WP_127625757.1 hydroxymethylglutaryl-CoA lyase -
N2598_RS20330 (N2598_20330) 502567..503352 + 786 WP_024312179.1 crotonase/enoyl-CoA hydratase family protein -
N2598_RS20335 (N2598_20335) 503427..503798 + 372 WP_018012058.1 DUF2384 domain-containing protein Antitoxin
N2598_RS20340 (N2598_20340) 503852..504304 + 453 WP_102046384.1 RES domain-containing protein Toxin
N2598_RS20345 (N2598_20345) 504429..505799 - 1371 WP_024325271.1 FAD-binding oxidoreductase -
N2598_RS20350 (N2598_20350) 505928..507031 - 1104 WP_012061474.1 sulfate/molybdate ABC transporter ATP-binding protein -
N2598_RS20355 (N2598_20355) 507047..507913 - 867 WP_024325272.1 sulfate ABC transporter permease subunit CysW -
N2598_RS20360 (N2598_20360) 507903..508769 - 867 WP_018209856.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..1534656 1534656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-143)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 16566.89 Da        Isoelectric Point: 5.5883

>T257344 WP_102046384.1 NZ_CP104148:503852-504304 [Sinorhizobium medicae]
MPLSGAGAARFGGRWNPVGVPALYAARELSTAWAEYNQGFVQHPALIVQLELRDAVLADLTDFKVLADLDVDETIHSCEW
RDMLDKGAVPQTHQLRTALLARDYHGVIYPSFMSPGGTCVALWRWNGAKEPRLDVIDPEGRLPKSPASWV

Download         Length: 453 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13189.32 Da        Isoelectric Point: 10.0414

>AT257344 WP_018012058.1 NZ_CP104148:503427-503798 [Sinorhizobium medicae]
MMAVEFQIAAARFGDEHSPFLSARLVADRLGVTLAELSKLIGVARNTLTAKSGARKVDSALSRVVRILAMASEMAGDETR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G1WRV9

References