Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3857159..3857816 Replicon chromosome
Accession NC_016514
Organism Enterobacter cloacae EcWSU1

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag ECWSU1_RS18330 Protein ID WP_014171514.1
Coordinates 3857159..3857569 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ECWSU1_RS18335 Protein ID WP_003863437.1
Coordinates 3857550..3857816 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECWSU1_RS18310 3853157..3854890 - 1734 WP_014171509.1 single-stranded-DNA-specific exonuclease RecJ -
ECWSU1_RS18315 3854896..3855609 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECWSU1_RS18320 3855633..3856529 - 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
ECWSU1_RS18325 3856631..3857152 + 522 WP_014171513.1 flavodoxin FldB -
ECWSU1_RS18330 3857159..3857569 - 411 WP_014171514.1 protein YgfX Toxin
ECWSU1_RS18335 3857550..3857816 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ECWSU1_RS18340 3858111..3859087 + 977 Protein_3611 tRNA-modifying protein YgfZ -
ECWSU1_RS18345 3859197..3859856 - 660 WP_014171517.1 hemolysin III family protein -
ECWSU1_RS18350 3860123..3860854 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
ECWSU1_RS18355 3860971..3862404 + 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T25732 WP_014171514.1 NC_016514:c3857569-3857159 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T25732 NC_016514:c3857569-3857159 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAACAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT25732 WP_003863437.1 NC_016514:c3857816-3857550 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT25732 NC_016514:c3857816-3857550 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCTATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References