257314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1011931..1012514 Replicon plasmid pC101a
Accession NZ_CP104135
Organism Sinorhizobium sp. C101

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N0R80_RS07670 Protein ID WP_275598126.1
Coordinates 1012260..1012514 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0R80_RS07665 Protein ID WP_275596559.1
Coordinates 1011931..1012263 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0R80_RS07625 (N0R80_07625) 1007280..1007600 - 321 WP_018094580.1 YnfA family protein -
N0R80_RS07630 (N0R80_07630) 1007677..1007850 - 174 WP_003527319.1 hypothetical protein -
N0R80_RS07635 (N0R80_07635) 1007864..1008037 - 174 WP_003527318.1 hypothetical protein -
N0R80_RS07640 (N0R80_07640) 1008273..1008974 + 702 WP_018094581.1 glutathione S-transferase N-terminal domain-containing protein -
N0R80_RS07645 (N0R80_07645) 1009056..1009397 - 342 WP_018094582.1 DUF2147 domain-containing protein -
N0R80_RS07650 (N0R80_07650) 1009989..1010255 + 267 WP_100672044.1 sel1 repeat family protein -
N0R80_RS07655 (N0R80_07655) 1010277..1011398 - 1122 WP_275596560.1 pyridoxal phosphate-dependent aminotransferase -
N0R80_RS07665 (N0R80_07665) 1011931..1012263 - 333 WP_275596559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0R80_RS07670 (N0R80_07670) 1012260..1012514 - 255 WP_275598126.1 type II toxin-antitoxin system HicA family toxin Toxin
N0R80_RS07675 (N0R80_07675) 1013360..1014383 + 1024 Protein_969 porin -
N0R80_RS07680 (N0R80_07680) 1014489..1015373 - 885 WP_234704905.1 site-specific integrase -
N0R80_RS07685 (N0R80_07685) 1015595..1016653 - 1059 WP_275599993.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / adeG / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521547 3521547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9493.96 Da        Isoelectric Point: 11.1842

>T257314 WP_275598126.1 NZ_CP104135:c1012514-1012260 [Sinorhizobium sp. C101]
MKKRRRATLELIFARPVNGSIRWVDIEALFVALGAEVSERQGSRTGVFLFGEVRVFHRPHPSPDTDKGAVASIRKWLDEH
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12062.77 Da        Isoelectric Point: 4.9602

>AT257314 WP_275596559.1 NZ_CP104135:c1012263-1011931 [Sinorhizobium sp. C101]
MNNVVEINGEKAVIAFDPEIKMLRGEFVALNGGADFYAESVHDLIEEGRKSLAVYLEMCREKGIEPRRKFSGKFNVRLTP
DEHAAAVIAAAAAGKSLNEWIVGTIREAAE

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References