257313

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 396803..397479 Replicon plasmid pC101a
Accession NZ_CP104135
Organism Sinorhizobium sp. C101

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N0R80_RS04680 Protein ID WP_275596863.1
Coordinates 397063..397479 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2N8K0L2
Locus tag N0R80_RS04675 Protein ID WP_018094055.1
Coordinates 396803..397066 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0R80_RS04645 (N0R80_04645) 391867..393073 + 1207 Protein_372 MFS transporter -
N0R80_RS04650 (N0R80_04650) 393070..393573 - 504 WP_275599960.1 TetR/AcrR family transcriptional regulator -
N0R80_RS04655 (N0R80_04655) 393682..394449 + 768 WP_275596865.1 SDR family NAD(P)-dependent oxidoreductase -
N0R80_RS04660 (N0R80_04660) 394470..394811 + 342 WP_100670025.1 carboxymuconolactone decarboxylase family protein -
N0R80_RS04665 (N0R80_04665) 395244..395942 - 699 WP_275596864.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
N0R80_RS04670 (N0R80_04670) 396137..396625 + 489 WP_100669718.1 RidA family protein -
N0R80_RS04675 (N0R80_04675) 396803..397066 + 264 WP_018094055.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N0R80_RS04680 (N0R80_04680) 397063..397479 + 417 WP_275596863.1 type II toxin-antitoxin system VapC family toxin Toxin
N0R80_RS04685 (N0R80_04685) 397476..398093 + 618 WP_275596862.1 hypothetical protein -
N0R80_RS04690 (N0R80_04690) 398185..399330 + 1146 WP_275596861.1 alpha-hydroxy acid oxidase -
N0R80_RS04695 (N0R80_04695) 399601..400071 - 471 WP_275596860.1 aminoacyl-tRNA deacylase -
N0R80_RS04700 (N0R80_04700) 400255..400932 - 678 WP_275596859.1 isoprenylcysteine carboxylmethyltransferase family protein -
N0R80_RS04705 (N0R80_04705) 401397..401828 - 432 WP_100669711.1 DUF1810 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / adeG / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521547 3521547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(11-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15391.92 Da        Isoelectric Point: 8.9532

>T257313 WP_275596863.1 NZ_CP104135:397063-397479 [Sinorhizobium sp. C101]
MSLWMLDTKIAGHVIKGDRPEIIDRLVSLPITDIVVSSVTEGELLYGLAKRGYPRTLSERVRQFLLRVDVLPWNRTAARS
YGDLRAACEAKGAALAPLDMMIAAHAVAFDAVLVTRDRAFTRVAEPLKTDDWTDQKLK

Download         Length: 417 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9846.96 Da        Isoelectric Point: 5.1708

>AT257313 WP_018094055.1 NZ_CP104135:396803-397066 [Sinorhizobium sp. C101]
VATKTAKIFASGRSQAVRLPAEFRFEGSEVFVRRDPKTGDVILSRKPDSWDGLFELYGKDQVGDDFLGPADRKQPSQDRD
PFEGWKE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8K0L2

References