Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1395366..1396173 Replicon plasmid pK101c
Accession NZ_CP104133
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag N0Q91_RS29865 Protein ID WP_100670374.1
Coordinates 1395366..1395890 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A2N8JWE8
Locus tag N0Q91_RS29870 Protein ID WP_018097027.1
Coordinates 1395883..1396173 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS29840 (N0Q91_29865) 1390466..1391323 + 858 WP_100670384.1 carbohydrate ABC transporter permease -
N0Q91_RS29845 (N0Q91_29870) 1391352..1392581 + 1230 WP_275599048.1 extracellular solute-binding protein -
N0Q91_RS29850 (N0Q91_29875) 1392670..1393800 + 1131 WP_275599049.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
N0Q91_RS29855 (N0Q91_29880) 1393803..1394303 + 501 WP_275599050.1 GNAT family N-acetyltransferase -
N0Q91_RS29860 (N0Q91_29885) 1394451..1394834 + 384 WP_102762399.1 VOC family protein -
N0Q91_RS29865 (N0Q91_29890) 1395366..1395890 - 525 WP_100670374.1 GNAT family N-acetyltransferase Toxin
N0Q91_RS29870 (N0Q91_29895) 1395883..1396173 - 291 WP_018097027.1 DUF1778 domain-containing protein Antitoxin
N0Q91_RS29875 (N0Q91_29900) 1396316..1396573 - 258 WP_018097026.1 hypothetical protein -
N0Q91_RS29880 (N0Q91_29905) 1396593..1397168 - 576 WP_275599051.1 thermonuclease family protein -
N0Q91_RS29885 (N0Q91_29910) 1397543..1399027 - 1485 WP_275599052.1 succinoglycan biosynthesis transport protein ExoT -
N0Q91_RS29890 (N0Q91_29915) 1399151..1400108 + 958 Protein_1312 succinoglycan biosynthesis glycosyltransferase ExoW -
N0Q91_RS29895 (N0Q91_29920) 1400223..1401173 + 951 WP_275599053.1 succinoglycan biosynthesis protein ExoV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..1695711 1695711


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 18532.30 Da        Isoelectric Point: 7.3207

>T257310 WP_100670374.1 NZ_CP104133:c1395890-1395366 [Sinorhizobium sp. K101]
VLDWREEPIGRHHDRKAFDCGTPELNEYLRRHARQNHEGGGSKTFVAVAPTAPETILGYYSISPASIAFAKVPAPLTKGL
GRYEVAVYRLARLAVALPLQGRGLGGDLLLAAGARALAVAAQVGGVALAIDAKDEKAACWYERFGAMPLLDSSPLSLILP
FKTIIDALDAAQGE

Download         Length: 525 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10730.29 Da        Isoelectric Point: 10.6264

>AT257310 WP_018097027.1 NZ_CP104133:c1396173-1395883 [Sinorhizobium sp. K101]
MAQMQANRDDRIELRTTRDEKRLLTAAAAHERLDVTSFIMRAVLPAAREVVENAERISLSERDSLRVLDLLENPPAPTPA
LLAAARRRIARDGKSA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8JWE8

References