Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 1244655..1245587 Replicon plasmid pK101c
Accession NZ_CP104133
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N0Q91_RS29210 Protein ID WP_275598965.1
Coordinates 1245033..1245587 (+) Length 185 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2N8JW20
Locus tag N0Q91_RS29205 Protein ID WP_018097157.1
Coordinates 1244655..1245026 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS29185 (N0Q91_29210) 1240541..1240924 + 384 WP_100670781.1 RidA family protein -
N0Q91_RS29190 (N0Q91_29215) 1240942..1242929 + 1988 Protein_1172 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
N0Q91_RS29195 (N0Q91_29220) 1242926..1243796 + 871 Protein_1173 hydroxymethylglutaryl-CoA lyase -
N0Q91_RS29200 (N0Q91_29225) 1243793..1244578 + 786 WP_275598964.1 crotonase/enoyl-CoA hydratase family protein -
N0Q91_RS29205 (N0Q91_29230) 1244655..1245026 + 372 WP_018097157.1 DUF2384 domain-containing protein Antitoxin
N0Q91_RS29210 (N0Q91_29235) 1245033..1245587 + 555 WP_275598965.1 RES family NAD+ phosphorylase Toxin
N0Q91_RS29215 (N0Q91_29240) 1246287..1247237 + 951 WP_275598966.1 IS110 family transposase -
N0Q91_RS29220 (N0Q91_29245) 1247547..1248911 - 1365 WP_275598967.1 FAD-binding oxidoreductase -
N0Q91_RS29225 (N0Q91_29250) 1249023..1250126 - 1104 WP_275598968.1 sulfate/molybdate ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..1695711 1695711


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(23-177)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20341.28 Da        Isoelectric Point: 6.7527

>T257309 WP_275598965.1 NZ_CP104133:1245033-1245587 [Sinorhizobium sp. K101]
MRKHSPLVSRPDPEPTASVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGVPAIYGARELSTAWAEYNQGFVQHPAL
IVQLELLGARLADLTDVSLLVELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDFHGVIYPSFMSPGGTCVALWRWN
GPQEPRLGVIDPDGRLPKSPASWV

Download         Length: 555 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13109.26 Da        Isoelectric Point: 9.9996

>AT257309 WP_018097157.1 NZ_CP104133:1244655-1245026 [Sinorhizobium sp. K101]
MIALDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8JW20

References