257305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 170695..171293 Replicon plasmid pK101b
Accession NZ_CP104132
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name relE Uniprot ID Q930F0
Locus tag N0Q91_RS20435 Protein ID WP_010967243.1
Coordinates 170695..170988 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N0Q91_RS20440 Protein ID WP_275598527.1
Coordinates 170985..171293 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS20405 (N0Q91_20415) 166201..166443 + 243 WP_275598523.1 hypothetical protein -
N0Q91_RS20410 (N0Q91_20420) 166492..166587 + 96 Protein_168 cold-shock protein -
N0Q91_RS20415 (N0Q91_20425) 166845..167237 - 393 WP_275598524.1 response regulator -
N0Q91_RS20420 (N0Q91_20430) 167445..168575 - 1131 WP_275598525.1 IS1595 family transposase -
N0Q91_RS20425 (N0Q91_20435) 168743..169044 - 302 Protein_171 plasmid partitioning protein RepB C-terminal domain-containing protein -
N0Q91_RS20430 (N0Q91_20440) 169235..170434 + 1200 WP_275598526.1 NAD-dependent formate dehydrogenase -
N0Q91_RS20435 (N0Q91_20445) 170695..170988 - 294 WP_010967243.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
N0Q91_RS20440 (N0Q91_20450) 170985..171293 - 309 WP_275598527.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N0Q91_RS20445 (N0Q91_20455) 171499..171927 - 429 WP_275598528.1 GNAT family N-acetyltransferase -
N0Q91_RS20450 (N0Q91_20460) 172940..173056 - 117 Protein_176 cation transporter -
N0Q91_RS20455 (N0Q91_20465) 173255..173788 + 534 Protein_177 short-chain dehydrogenase -
N0Q91_RS20460 (N0Q91_20470) 173973..174200 - 228 WP_003525968.1 hypothetical protein -
N0Q91_RS20465 (N0Q91_20475) 174277..175170 - 894 WP_275598529.1 AraC family transcriptional regulator -
N0Q91_RS20470 (N0Q91_20480) 175383..175784 - 402 WP_275598530.1 periplasmic heavy metal sensor -
N0Q91_RS20475 (N0Q91_20485) 175781..176230 - 450 WP_275598531.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..772620 772620
- flank IS/Tn - - 167445..168575 1130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-60)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11278.93 Da        Isoelectric Point: 6.4734

>T257305 WP_010967243.1 NZ_CP104132:c170988-170695 [Sinorhizobium sp. K101]
MRLVWARYALDDRDTIFSYIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Download         Length: 294 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11224.61 Da        Isoelectric Point: 5.6604

>AT257305 WP_275598527.1 NZ_CP104132:c171293-170985 [Sinorhizobium sp. K101]
MASNALVQTRIDAEIKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAALRKAAAGDR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q930F0

Antitoxin

Source ID Structure

References