257304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3505854..3506419 Replicon plasmid pK101a
Accession NZ_CP104131
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name brnT Uniprot ID A0A2N8JYP0
Locus tag N0Q91_RS19500 Protein ID WP_018099710.1
Coordinates 3506174..3506419 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag N0Q91_RS19495 Protein ID WP_275597250.1
Coordinates 3505854..3506177 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS19475 (N0Q91_19485) 3501497..3502672 - 1176 WP_275597247.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
N0Q91_RS19480 (N0Q91_19490) 3502831..3503556 + 726 WP_275597248.1 META domain-containing protein -
N0Q91_RS19485 (N0Q91_19495) 3503922..3504089 - 168 WP_018097235.1 hypothetical protein -
N0Q91_RS19490 (N0Q91_19500) 3504284..3505474 - 1191 WP_275597249.1 calcium-binding protein -
N0Q91_RS19495 (N0Q91_19505) 3505854..3506177 - 324 WP_275597250.1 BrnA antitoxin family protein Antitoxin
N0Q91_RS19500 (N0Q91_19510) 3506174..3506419 - 246 WP_018099710.1 BrnT family toxin Toxin
N0Q91_RS19510 (N0Q91_19520) 3507110..3508006 + 897 WP_275597251.1 ROK family protein -
N0Q91_RS19515 (N0Q91_19525) 3508081..3508575 + 495 WP_275597252.1 heme-degrading domain-containing protein -
N0Q91_RS19520 (N0Q91_19530) 3508586..3509749 + 1164 WP_275597253.1 mannose-6-phosphate isomerase Pmi -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pgm / acpXL / kdsA / tufA / tufA / acpXL / htpB / icl / fliQ / adeG / kdsB 1..3521393 3521393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-101)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9056.49 Da        Isoelectric Point: 9.7323

>T257304 WP_018099710.1 NZ_CP104131:c3506419-3506174 [Sinorhizobium sp. K101]
MKITYDETKRQTNIGKHAYDFAELDMEFFSSSVVVPAKEGRFMAIGVLRNGVIAVVFARLGSEGISIISMRDASRKERSL
L

Download         Length: 246 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12129.72 Da        Isoelectric Point: 10.2817

>AT257304 WP_275597250.1 NZ_CP104131:c3506177-3505854 [Sinorhizobium sp. K101]
MTNPSRRIRHISDKEEAEIQRKIASDPDAPEATDEQLRQAKPFAEAFPDLAESIKRARGRPAIEKPRQQLSIRLDPDIIE
HYKATGKGWQSRMNDDLRKAAGLKKAG

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8JYP0

Antitoxin

Source ID Structure

References