257302

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2065773..2066356 Replicon plasmid pK101a
Accession NZ_CP104131
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N0Q91_RS12615 Protein ID WP_275598126.1
Coordinates 2065773..2066027 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0Q91_RS12620 Protein ID WP_275596559.1
Coordinates 2066024..2066356 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS12600 (N0Q91_12610) 2061635..2062693 + 1059 WP_275596557.1 porin -
N0Q91_RS12605 (N0Q91_12615) 2062915..2063799 + 885 WP_234704905.1 site-specific integrase -
N0Q91_RS12610 (N0Q91_12620) 2063905..2064927 - 1023 WP_275596558.1 porin -
N0Q91_RS12615 (N0Q91_12625) 2065773..2066027 + 255 WP_275598126.1 type II toxin-antitoxin system HicA family toxin Toxin
N0Q91_RS12620 (N0Q91_12630) 2066024..2066356 + 333 WP_275596559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0Q91_RS12630 (N0Q91_12640) 2066889..2068010 + 1122 WP_275596560.1 pyridoxal phosphate-dependent aminotransferase -
N0Q91_RS12635 (N0Q91_12645) 2068032..2068298 - 267 WP_100672044.1 sel1 repeat family protein -
N0Q91_RS12640 (N0Q91_12650) 2068890..2069231 + 342 WP_018094582.1 DUF2147 domain-containing protein -
N0Q91_RS12645 (N0Q91_12655) 2069312..2070014 - 703 Protein_1948 glutathione S-transferase N-terminal domain-containing protein -
N0Q91_RS12650 (N0Q91_12660) 2070250..2070423 + 174 WP_003527318.1 hypothetical protein -
N0Q91_RS12655 (N0Q91_12665) 2070437..2070610 + 174 WP_003527319.1 hypothetical protein -
N0Q91_RS12660 (N0Q91_12670) 2070687..2071007 + 321 WP_018094580.1 YnfA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pgm / acpXL / kdsA / tufA / tufA / acpXL / htpB / icl / fliQ / adeG / kdsB 1..3521393 3521393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9493.96 Da        Isoelectric Point: 11.1842

>T257302 WP_275598126.1 NZ_CP104131:2065773-2066027 [Sinorhizobium sp. K101]
MKKRRRATLELIFARPVNGSIRWVDIEALFVALGAEVSERQGSRTGVFLFGEVRVFHRPHPSPDTDKGAVASIRKWLDEH
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12062.77 Da        Isoelectric Point: 4.9602

>AT257302 WP_275596559.1 NZ_CP104131:2066024-2066356 [Sinorhizobium sp. K101]
MNNVVEINGEKAVIAFDPEIKMLRGEFVALNGGADFYAESVHDLIEEGRKSLAVYLEMCREKGIEPRRKFSGKFNVRLTP
DEHAAAVIAAAAAGKSLNEWIVGTIREAAE

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References