Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 1619266..1619788 Replicon plasmid pK101a
Accession NZ_CP104131
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name relE Uniprot ID A0A2N8JTE7
Locus tag N0Q91_RS10385 Protein ID WP_018097784.1
Coordinates 1619501..1619788 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2N8JTF1
Locus tag N0Q91_RS10380 Protein ID WP_026168897.1
Coordinates 1619266..1619511 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS10360 (N0Q91_10370) 1614753..1615778 + 1026 WP_100673922.1 amino acid ABC transporter substrate-binding protein -
N0Q91_RS10365 (N0Q91_10375) 1615883..1617076 + 1194 WP_275598023.1 amino acid ABC transporter permease -
N0Q91_RS10370 (N0Q91_10380) 1617081..1618235 + 1155 WP_100673923.1 amino acid ABC transporter permease -
N0Q91_RS10375 (N0Q91_10385) 1618252..1619028 + 777 WP_100673924.1 amino acid ABC transporter ATP-binding protein -
N0Q91_RS10380 (N0Q91_10390) 1619266..1619511 + 246 WP_026168897.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N0Q91_RS10385 (N0Q91_10395) 1619501..1619788 + 288 WP_018097784.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0Q91_RS10390 (N0Q91_10400) 1620070..1620882 - 813 WP_018097785.1 ferredoxin--NADP reductase -
N0Q91_RS10395 (N0Q91_10405) 1621027..1621527 - 501 WP_275598024.1 DUF934 domain-containing protein -
N0Q91_RS10400 (N0Q91_10410) 1621545..1623218 - 1674 WP_100673926.1 nitrite/sulfite reductase -
N0Q91_RS10405 (N0Q91_10415) 1623233..1623550 - 318 WP_018097788.1 DUF2849 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pgm / acpXL / kdsA / tufA / tufA / acpXL / htpB / icl / fliQ / adeG / kdsB 1..3521393 3521393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11088.01 Da        Isoelectric Point: 11.1450

>T257301 WP_018097784.1 NZ_CP104131:1619501-1619788 [Sinorhizobium sp. K101]
MPYSLEFLPSARKEWDKLGATIRQQFVKKLRERLERPRIPSAALSGMPDHYKIKLRQLGYRLVYRVDDGTVIVLVVAVGK
RERGDVYNTMRARGR

Download         Length: 288 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8889.14 Da        Isoelectric Point: 4.1712

>AT257301 WP_026168897.1 NZ_CP104131:1619266-1619511 [Sinorhizobium sp. K101]
MQRVEASVAVSVSDLKKSPTAVMGEAQGEAVAVLNHNRVMAYLVPAEVYESMLERLDDLYLAELVKERAEEKGEPVDIDA
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8JTE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8JTF1

References