257293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 459750..460330 Replicon plasmid pM103b
Accession NZ_CP104128
Organism Sinorhizobium sp. M103

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N0Q90_RS21890 Protein ID WP_275598578.1
Coordinates 459947..460330 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N0Q90_RS21885 Protein ID WP_275598577.1
Coordinates 459750..459950 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q90_RS21870 (N0Q90_21875) 455586..456383 + 798 WP_275598573.1 ABC transporter ATP-binding protein -
N0Q90_RS21875 (N0Q90_21880) 456355..457056 - 702 WP_275598574.1 class I SAM-dependent methyltransferase -
N0Q90_RS21880 (N0Q90_21885) 457421..459370 - 1950 WP_275602654.1 calcium-binding protein -
N0Q90_RS21885 (N0Q90_21890) 459750..459950 + 201 WP_275598577.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N0Q90_RS21890 (N0Q90_21895) 459947..460330 + 384 WP_275598578.1 type II toxin-antitoxin system VapC family toxin Toxin
N0Q90_RS21895 (N0Q90_21900) 460423..460812 - 390 WP_102761961.1 ester cyclase -
N0Q90_RS21900 (N0Q90_21905) 461154..461576 - 423 WP_275598579.1 type II toxin-antitoxin system VapC family toxin -
N0Q90_RS21905 (N0Q90_21910) 461573..461827 - 255 WP_275598580.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
N0Q90_RS21910 (N0Q90_21915) 461979..462599 - 621 WP_275598581.1 hypothetical protein -
N0Q90_RS21915 (N0Q90_21920) 463331..464005 - 675 WP_275602695.1 MarR family winged helix-turn-helix transcriptional regulator -
N0Q90_RS21920 (N0Q90_21925) 464375..464788 - 414 WP_275598582.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..772647 772647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14269.53 Da        Isoelectric Point: 7.5964

>T257293 WP_275598578.1 NZ_CP104128:459947-460330 [Sinorhizobium sp. M103]
VILADTSIWIDHFRHTDAELRRIVEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHHEVMMMVDRHAIFSM
GIGYTDAHLLASVLLDKRVALWTRDKRLRAAAEKAGASLHTPAHTRN

Download         Length: 384 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7011.11 Da        Isoelectric Point: 10.7473

>AT257293 WP_275598577.1 NZ_CP104128:459750-459950 [Sinorhizobium sp. M103]
MRSTINLDDALMETAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References