257291

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3093304..3093869 Replicon plasmid pM103a
Accession NZ_CP104127
Organism Sinorhizobium sp. M103

Toxin (Protein)


Gene name brnT Uniprot ID A0A2N8JYP0
Locus tag N0Q90_RS17675 Protein ID WP_018099710.1
Coordinates 3093304..3093549 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag N0Q90_RS17680 Protein ID WP_275597250.1
Coordinates 3093546..3093869 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q90_RS17655 (N0Q90_17655) 3089974..3091137 - 1164 WP_275597253.1 mannose-6-phosphate isomerase Pmi -
N0Q90_RS17660 (N0Q90_17660) 3091148..3091642 - 495 WP_275597252.1 heme-degrading domain-containing protein -
N0Q90_RS17665 (N0Q90_17665) 3091717..3092613 - 897 WP_275597251.1 ROK family protein -
N0Q90_RS17675 (N0Q90_17675) 3093304..3093549 + 246 WP_018099710.1 BrnT family toxin Toxin
N0Q90_RS17680 (N0Q90_17680) 3093546..3093869 + 324 WP_275597250.1 BrnA antitoxin family protein Antitoxin
N0Q90_RS17685 (N0Q90_17685) 3094249..3095439 + 1191 WP_275602557.1 calcium-binding protein -
N0Q90_RS17690 (N0Q90_17690) 3095634..3095801 + 168 WP_018097235.1 hypothetical protein -
N0Q90_RS17695 (N0Q90_17695) 3096167..3096892 - 726 WP_275597248.1 META domain-containing protein -
N0Q90_RS17700 (N0Q90_17700) 3097051..3098226 + 1176 WP_275597247.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / fliE / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521513 3521513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-101)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9056.49 Da        Isoelectric Point: 9.7323

>T257291 WP_018099710.1 NZ_CP104127:3093304-3093549 [Sinorhizobium sp. M103]
MKITYDETKRQTNIGKHAYDFAELDMEFFSSSVVVPAKEGRFMAIGVLRNGVIAVVFARLGSEGISIISMRDASRKERSL
L

Download         Length: 246 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12129.72 Da        Isoelectric Point: 10.2817

>AT257291 WP_275597250.1 NZ_CP104127:3093546-3093869 [Sinorhizobium sp. M103]
MTNPSRRIRHISDKEEAEIQRKIASDPDAPEATDEQLRQAKPFAEAFPDLAESIKRARGRPAIEKPRQQLSIRLDPDIIE
HYKATGKGWQSRMNDDLRKAAGLKKAG

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8JYP0

Antitoxin

Source ID Structure

References