257288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1011923..1012506 Replicon plasmid pM103a
Accession NZ_CP104127
Organism Sinorhizobium sp. M103

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N0Q90_RS07695 Protein ID WP_275598126.1
Coordinates 1012252..1012506 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0Q90_RS07690 Protein ID WP_275596559.1
Coordinates 1011923..1012255 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q90_RS07650 (N0Q90_07650) 1007272..1007592 - 321 WP_018094580.1 YnfA family protein -
N0Q90_RS07655 (N0Q90_07655) 1007669..1007842 - 174 WP_003527319.1 hypothetical protein -
N0Q90_RS07660 (N0Q90_07660) 1007856..1008029 - 174 WP_003527318.1 hypothetical protein -
N0Q90_RS07665 (N0Q90_07665) 1008265..1008966 + 702 WP_018094581.1 glutathione S-transferase N-terminal domain-containing protein -
N0Q90_RS07670 (N0Q90_07670) 1009048..1009389 - 342 WP_018094582.1 DUF2147 domain-containing protein -
N0Q90_RS07675 (N0Q90_07675) 1009981..1010247 + 267 WP_100672044.1 sel1 repeat family protein -
N0Q90_RS07680 (N0Q90_07680) 1010269..1011390 - 1122 WP_275596560.1 pyridoxal phosphate-dependent aminotransferase -
N0Q90_RS07690 (N0Q90_07690) 1011923..1012255 - 333 WP_275596559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0Q90_RS07695 (N0Q90_07695) 1012252..1012506 - 255 WP_275598126.1 type II toxin-antitoxin system HicA family toxin Toxin
N0Q90_RS07700 (N0Q90_07700) 1013351..1014373 + 1023 WP_275596558.1 porin -
N0Q90_RS07705 (N0Q90_07705) 1014479..1015363 - 885 WP_234704905.1 site-specific integrase -
N0Q90_RS07710 (N0Q90_07710) 1015585..1016642 - 1058 Protein_971 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / fliE / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521513 3521513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9493.96 Da        Isoelectric Point: 11.1842

>T257288 WP_275598126.1 NZ_CP104127:c1012506-1012252 [Sinorhizobium sp. M103]
MKKRRRATLELIFARPVNGSIRWVDIEALFVALGAEVSERQGSRTGVFLFGEVRVFHRPHPSPDTDKGAVASIRKWLDEH
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12062.77 Da        Isoelectric Point: 4.9602

>AT257288 WP_275596559.1 NZ_CP104127:c1012255-1011923 [Sinorhizobium sp. M103]
MNNVVEINGEKAVIAFDPEIKMLRGEFVALNGGADFYAESVHDLIEEGRKSLAVYLEMCREKGIEPRRKFSGKFNVRLTP
DEHAAAVIAAAAAGKSLNEWIVGTIREAAE

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References