257287

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 396809..397485 Replicon plasmid pM103a
Accession NZ_CP104127
Organism Sinorhizobium sp. M103

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N0Q90_RS04710 Protein ID WP_275596863.1
Coordinates 397069..397485 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2N8K0L2
Locus tag N0Q90_RS04705 Protein ID WP_018094055.1
Coordinates 396809..397072 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q90_RS04675 (N0Q90_04675) 391873..393079 + 1207 Protein_373 MFS transporter -
N0Q90_RS04680 (N0Q90_04680) 393076..393579 - 504 WP_275599960.1 TetR/AcrR family transcriptional regulator -
N0Q90_RS04685 (N0Q90_04685) 393688..394455 + 768 WP_275596865.1 SDR family NAD(P)-dependent oxidoreductase -
N0Q90_RS04690 (N0Q90_04690) 394476..394817 + 342 WP_100670025.1 carboxymuconolactone decarboxylase family protein -
N0Q90_RS04695 (N0Q90_04695) 395250..395948 - 699 WP_275596864.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
N0Q90_RS04700 (N0Q90_04700) 396143..396631 + 489 WP_100669718.1 RidA family protein -
N0Q90_RS04705 (N0Q90_04705) 396809..397072 + 264 WP_018094055.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N0Q90_RS04710 (N0Q90_04710) 397069..397485 + 417 WP_275596863.1 type II toxin-antitoxin system VapC family toxin Toxin
N0Q90_RS04715 (N0Q90_04715) 397482..398099 + 618 WP_275596862.1 hypothetical protein -
N0Q90_RS04720 (N0Q90_04720) 398191..399336 + 1146 WP_275596861.1 alpha-hydroxy acid oxidase -
N0Q90_RS04725 (N0Q90_04725) 399607..400077 - 471 WP_275596860.1 aminoacyl-tRNA deacylase -
N0Q90_RS04730 (N0Q90_04730) 400261..400938 - 678 WP_275596859.1 isoprenylcysteine carboxylmethyltransferase family protein -
N0Q90_RS04735 (N0Q90_04735) 401403..401834 - 432 WP_100669711.1 DUF1810 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / fliE / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521513 3521513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(11-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15391.92 Da        Isoelectric Point: 8.9532

>T257287 WP_275596863.1 NZ_CP104127:397069-397485 [Sinorhizobium sp. M103]
MSLWMLDTKIAGHVIKGDRPEIIDRLVSLPITDIVVSSVTEGELLYGLAKRGYPRTLSERVRQFLLRVDVLPWNRTAARS
YGDLRAACEAKGAALAPLDMMIAAHAVAFDAVLVTRDRAFTRVAEPLKTDDWTDQKLK

Download         Length: 417 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9846.96 Da        Isoelectric Point: 5.1708

>AT257287 WP_018094055.1 NZ_CP104127:396809-397072 [Sinorhizobium sp. M103]
VATKTAKIFASGRSQAVRLPAEFRFEGSEVFVRRDPKTGDVILSRKPDSWDGLFELYGKDQVGDDFLGPADRKQPSQDRD
PFEGWKE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8K0L2

References