Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3677889..3678592 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8H9SVB9
Locus tag N1705_RS17665 Protein ID WP_072003801.1
Coordinates 3677889..3678254 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8H9SW74
Locus tag N1705_RS17670 Protein ID WP_032250315.1
Coordinates 3678275..3678592 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS17645 (3673670) 3673670..3675085 - 1416 WP_001332875.1 undecaprenyl-phosphate glucose phosphotransferase -
N1705_RS17650 (3675402) 3675402..3676099 + 698 WP_225103636.1 IS1 family transposase -
N1705_RS17655 (3676236) 3676236..3676487 - 252 WP_196613384.1 hypothetical protein -
N1705_RS17660 (3676456) 3676456..3677436 - 981 WP_001082070.1 SMEK domain-containing protein -
N1705_RS17665 (3677889) 3677889..3678254 - 366 WP_072003801.1 TA system toxin CbtA family protein Toxin
N1705_RS17670 (3678275) 3678275..3678592 - 318 WP_032250315.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N1705_RS17675 (3678611) 3678611..3678832 - 222 Protein_3460 DUF987 domain-containing protein -
N1705_RS17680 (3678841) 3678841..3679323 - 483 WP_032250314.1 DNA repair protein RadC -
N1705_RS17685 (3679332) 3679332..3679790 - 459 WP_032250313.1 antirestriction protein -
N1705_RS17690 (3679893) 3679893..3680057 - 165 Protein_3463 DUF905 domain-containing protein -
N1705_RS17695 (3680391) 3680391..3682055 - 1665 WP_032250311.1 ATP-dependent helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3675806..3726103 50297
- flank IS/Tn - - 3675806..3676099 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13583.80 Da        Isoelectric Point: 8.8806

>T257280 WP_072003801.1 NZ_CP104123:c3678254-3677889 [Escherichia coli]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLKKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKHELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSR

Download         Length: 366 bp

>T257280 NZ_CP104123:c3678254-3677889 [Escherichia coli]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGAAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATCAAACCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCTGTTAACTTTCTTGTAGAAAAGCATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACTGTGACTGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11873.59 Da        Isoelectric Point: 6.8407

>AT257280 WP_032250315.1 NZ_CP104123:c3678592-3678275 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPQFISQMESMLTTGEMNPRHAHCVILYH
NGFTCEADTFGSCGYVYIAIYPIQR

Download         Length: 318 bp

>AT257280 NZ_CP104123:c3678592-3678275 [Escherichia coli]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
AATTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCATCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCTTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCATTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References